از غدد شروع ميكنم...ديابت را مي خونم..
پيشگيري با متفورمين در ديابت نوع 2: متفورمين در بيماران مبتلا به IGF وLGT وبيماراني كه ريسك ابتلا
آنهابه ديابت بسيار بالامي باشد انديكاسيون دارد:
1:بيماران با سن زير 60 سال
2:BMI مساوي يا بيشتر از 35
3:سابقه فاميلي ديابت در بستگان درجه اول
4:افزايش تري گليسيريد
5:كاهش HDL
6:هيپرتانسيون
7:هموگلوبين A1C بيشتر از 6%
تست:
مردي 43 ساله با قند خون ناشتا 107 به شما مراجعه كرده است.پدرش ديابتي است.
وزن 85 كيلوگرم و قد 165 سانتي متر و فشار خون 120/70 ميليمتر جيوه دارد.
در آزمايشهاي انجام شده تكرار قند خون ناشتا 106 mg/dl وقند 2 ساعت بعد از
دريافت 75 گرم گلوكز mg/dl 193 بود.سطح HDL-C كلسترول مساوي mg/dl 25 و
تري گليسريد350 mg/dl مي باشد.مناسبترين درمان براي اين بيمار كدام است؟
الف:پيوگليتازون
ب:متفورمين
ج:اورليستات
د:آكاربوزتو AOM پارسال روي اين نكته به اين صورت تاكيد نشده بود ..
دوستان هم لطفا نظر بدن..ممكنه امسال مثلا به اين صورت سوال بياد..
در اين تست بيمار چند تا ريسك فاكتور داره ؟؟؟(كلا 7 تاست)..:
PREVENTIONType 2 DM is preceded by a period of IGT, and a number of lifestyle modifications and pharmacologic agents prevent or delay the onset of DM. The Diabetes Prevention Program (DPP) demonstrated that intensive changes in lifestyle (diet and exercise for 30 min/day five times/week) in individuals with IGT prevented or delayed the development of type 2 DM by 58% compared to placebo. This effect was seen in individuals regardless of age, sex, or ethnic group. In the same study, metformin prevented or delayed diabetes by 31% compared to placebo. The lifestyle intervention group lost 5–7% of their body weight during the 3 years of the study. Studies in Finnish and Chinese populations noted similar efficacy of diet and exercise in preventing or delaying type 2 DM; acarbose, metformin, thiazolidinediones, and orlistat prevent or delay type 2 DM but are not approved for this purpose. When administered to nondiabetic individuals for other reasons (cardiac, cholesterol lowering, etc.), pravastatin reduced the number of new cases of diabetes. Individuals with a strong family history of type 2 DM and individuals with IFG or IGT should be strongly encouraged to maintain a normal BMI and engage in regular physical activity. Pharmacologic therapy for individuals with prediabetes is currently controversial because its cost-effectiveness and safety profile are not known.
***** A recent ADA Consensus panel concluded that metformin, but not other medications, could be considered in individuals with both IFG and IGT who are at very high risk for progression to diabetes (age < 60 years, BMI 35 kg/m2, family history of diabetes in first-degree relative, elevated triglycerides, reduced HDL, hypertension, or A1C > 6.0%)*****.
